While playing Kingdom of Loathing, me and my clan were doing a raid. For those who have played, it was in Hobopolis against Uberhodgman trying to acquire the Imaginary Hamster (it's... a weird game), and it was maybe three minutes until rollover (nightly maintenance where they boot everyone from the game for a half hour). I was the only one high enough level to fight Uberhodgman. About 90 seconds from rollover now and right before the killing blow, my fucking computer AUTOMATICALLY REBOOTED ITSELF. Like someone had walked by and pressed the reset button.
When I came back, after clicking away the "Your computer has recovered from a serious error" message, rollover had just begun. That crash cost my clan the whole raid. That was the only time in my life I turned violent with hardware: I smacked my monitor so hard it flipped through the air and smashed against the wall. Surprisingly, the tough little flat panel survived without a dent; it serves me well to this day.
By the way I found what caused the crash (it happened two more times): Avast!.... lousy anti-viruses causing more grief than any worm or trojan...