Game: Easiest / Hardest Buster-Only / Hardest w. Weapon:
MM1: Elec (exploitable AI) / Elec (3-hit kill if you don't know how to exploit AI) / Elec
MM2: Flash (two-pellet damage from buster in Hard Normal Mode, Za Warudo doesn't happen often enough to be a concern. / Quick (he's just that annoying to buster only) / Quick (weakness doesn't finish 'em off)
MM3: Top (two-pellet damage from buster) / Shadow (annoying and fast to buster-only) / Gemini (get in face and use a muthafuckin snake)
MM4: Toad (as others have mentioned) / Ring (Rings and collision damage is not nice) / Dive (get in face with skulls)
MM5: Just about everyone but Crystal / Crystal / Crystal
MM6: Knight / Tomahawk / Tomahawk (you only get seven Plant Barriers...)
MM7: Junk / Turbo / Turbo (although even he's not too bad with Noise)
MM8: Grenade / Search / Asshole Astro (hit the damn body, not the pods!!!)
MM9: Splash / Plug / ...maybe Concrete?
MM10: Blade (if you know what you're doing) / Solar / Nitro
MM&B: Cold / Burner&Dynamo / Burner&Dynamo (have to push with Ice Wall&LOL Health Regen)